Nani was brought up in Hyderabad, Andhra Pradesh, India (now in Telangana, India). He has one sister, Deepthi. He did his schooling from St. Alphonsa's High School and then studied in Narayana Junior College, S.R Nagar before graduating from Wesley's.
Nani got engaged on 12 August 2012, to his girlfriend of five years, Anjana Yelavarthy. Speaking to Hyderabad Times, the actor said, "We exchanged rings in a simple ceremony in Vizag that was attended by both our families." They got married on 27 October that year, in a private ceremony in Vizag.